The best selective and multi-target serotonin 5-HT6 receptor antagonists for the treatment of CNS diseases such as cognitive dysfunction, neurodegenerative and anxiety disorders, which affect millions of people worldwide.


AVISETRON (AVN-211) is a highly selective 5-HT6 receptor antagonist (IC50 = 6 nM, Kib=2.1 nM). It has a lesser affinity towards 5-HT2B, receptors (IC50 = 249 nM) and practically no affinity to a multitude of other therapeutic targets.

AVISETRON is in Phase II/III Clinical trials for the treatment of Schizophrenia.
AVN-322 is a highly selective 5-HT6 receptor antagonist with a high binding affinity (Ki=389 pM) and high potency to functionally block the receptor (Ki = 2.85±0.46 nM). The AVN-322 has a much lesser affinity towards 5HT-2B receptors (IC50~1 µM in radioligand competitive binding assay and 6.2 µM in a cell-based functional assay). The AVN-322 does not interact at 1 µM with other therapeutic targets (a panel of 70 receptors and enzymes}.

AVN-322 is ready to entering Phase II clinical trials for treating diseases associated with cognitive dysfunction.

Backup compounds AVN-492, AVN- 3205 are in preclinical development.

AVISETRON, AVN-322, AVN-492, and AVN- 3205 possess excellent DMPK/tox and behavioral profiles.


AVN-101 is safe and orally bioavailable multi-target drug candidate with potential for treatment of the CNS diseases associated with memory loss, cognitive dysfunction, neurodegeneration, depression, and general anxiety.

AVN-101 is a substance with a very high affinity to the 5-HT7 receptor (Ki=153 pM). It has a lesser affinity towards 5-HT6, 5-HT2A, and 5HT2C receptors (Ki range between 1.2 and 2.0 nM) and it also exhibits relatively high affinity towards histamine H1 (Ki = 580 pM), adrenergic ?2A, ?2B, and ?2C receptors (Ki range between 410 and 3,600 pM).

AVN-101 possess excellent DMPK/tox and behavioral profiles.

AVN-101 is now in clinical development for the treatment of disorders associated with the general anxiety and cognitive dysfunctions.


AVN 211 AVN 322 AVN 101 AVN 3085 AVN 3205 AVN 0189